Affinity Data by PubMed id=31757666

Found 1 hit of Enzyme Inhibition Constant Data

G protein-coupled receptor kinase 4(Homo sapiens (Human))
Merck & Co.

Curated by ChEMBL

BDBM50537742(CHEMBL4634634 | US11179389, Compound 1-14)copy SMILEScopy InChI

IC50: 3.47E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged GRK4 expressed in baculovirus expression system using serine/threonine-16 peptide as substrate...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Purchase MCE
PC cid PC sid PDB

Details Article
BindingDB Entry DOI: 10.7270/Q2HM5CZGPubMed

Displayed 1 to 50 (of 314 total ) | Next | Last >>* indicates data uncertainty>20%

Targets 245 ▿
- Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform 26
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 18
- Tyrosine-protein kinase ABL1 5
- Epidermal growth factor receptor 5
- Tyrosine-protein kinase JAK2 4
- Platelet-derived growth factor receptor alpha 4
- Proto-oncogene tyrosine-protein kinase receptor Ret 3
- Receptor-type tyrosine-protein kinase FLT3 2
- Mast/stem cell growth factor receptor Kit 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Hepatocyte growth factor receptor 2
- Protein kinase C beta type 2
- Mitogen-activated protein kinase 10 2
- Mitogen-activated protein kinase 14 2
- Tyrosine-protein kinase Lyn 2
- Serine/threonine-protein kinase B-raf 2
- Cyclin-dependent kinase 5 activator 1 2
- Fibroblast growth factor receptor 3 2
- Serine/threonine-protein kinase haspin 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase JAK1 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- Protein kinase C iota type 1
- NUAK family SNF1-like kinase 1 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 1
- Sphingosine kinase 1 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Dual specificity mitogen-activated protein kinase kinase 2 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase PAK 5 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Sphingosine kinase 2 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk1 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Serine/threonine-protein kinase Sgk3 1
- Casein kinase I isoform epsilon 1
- Casein kinase I isoform gamma-1 1
- Ephrin type-A receptor 1 1
- Ephrin type-A receptor 3 1
- Ephrin type-A receptor 2 1
- Ephrin type-A receptor 5 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Tyrosine-protein kinase receptor UFO 1
- DNA-dependent protein kinase catalytic subunit 1
- Insulin-like growth factor 1 receptor 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Myosin light chain kinase 2, skeletal/cardiac muscle 1
- Cytochrome P450 2C9 1
- Voltage-dependent L-type calcium channel subunit alpha-1C 1
- Tyrosine-protein kinase Srms 1
- Phosphatidylinositol 3-kinase catalytic subunit type 3 1
- Focal adhesion kinase 1 1
- Tyrosine-protein kinase TXK 1
- Rhodopsin kinase GRK7 1
- Ephrin type-A receptor 8 1
- Phosphatidylinositol 4-kinase beta 1
- Cytochrome P450 2D6 1
- Death-associated protein kinase 1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Serine/threonine-protein kinase D1 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Death-associated protein kinase 3 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Sodium channel protein type 5 subunit alpha 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Testis-specific serine/threonine-protein kinase 2 1
- Protein-tyrosine kinase 6 1
- Casein kinase II subunit alpha 1
- Leukocyte tyrosine kinase receptor 1
- Cytoplasmic tyrosine-protein kinase BMX 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2/subunit beta-1/subunit gamma-1 1
- Tyrosine-protein kinase ABL2 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- Rho-associated protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Rho-associated protein kinase 1 1
- Serine/threonine-protein kinase SIK2 1
- Tyrosine-protein kinase Fes/Fps 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Mitogen-activated protein kinase 3 1
- Serine/threonine-protein kinase 4 1
- SRSF protein kinase 3 1
- Mitogen-activated protein kinase 9 1
- SRSF protein kinase 2 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Serine/threonine-protein kinase TBK1 1
- SRC kinase signaling inhibitor 1 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Tyrosine-protein kinase HCK 1
- Vascular endothelial growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Serine/threonine-protein kinase PLK2 1
- Insulin receptor-related protein 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase PLK3 1
- Tyrosine-protein kinase receptor TYRO3 1
- Serine/threonine-protein kinase BRSK1 1
- Protein kinase C gamma type 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Protein kinase C zeta type 1
- Eukaryotic elongation factor 2 kinase 1
- Serine/threonine-protein kinase Chk2 1
- Phosphatidylinositol 4-kinase alpha 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Tyrosine-protein kinase Yes 1
- Serine/threonine-protein kinase MRCK beta 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 4 1
- Casein kinase II subunit alpha' 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 3 1
- Receptor tyrosine-protein kinase erbB-4 1
- Receptor tyrosine-protein kinase erbB-2 1
- Tyrosine-protein kinase FRK 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Serine/threonine-protein kinase Nek6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- MAP/microtubule affinity-regulating kinase 3 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- MAP/microtubule affinity-regulating kinase 4 1
- Serine/threonine-protein kinase mTOR 1
- Tyrosine-protein kinase ITK/TSK 1
- Protein kinase C eta type 1
- Tyrosine-protein kinase Blk 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Ribosomal protein S6 kinase beta-1 1
- Casein kinase I isoform delta 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Serine/threonine-protein kinase 24 1
- Serine/threonine-protein kinase 25 1
- Ephrin type-B receptor 3 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 1 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 3 1
- Platelet-derived growth factor receptor beta 1
- MAP kinase-activated protein kinase 5 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Tyrosine-protein kinase Fer 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- PAS domain-containing serine/threonine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Beta-adrenergic receptor kinase 2 1
- Beta-adrenergic receptor kinase 1 1
- Serine/threonine-protein kinase DCLK2 1
- Serine/threonine-protein kinase TAO2 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase kinase kinase kinase 5 1
- Nuclear receptor subfamily 1 group I member 2 1
- Activin receptor type-1B 1
- Interleukin-1 receptor-associated kinase 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- RAC-alpha serine/threonine-protein kinase 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Proto-oncogene tyrosine-protein kinase Src 1
- BDNF/NT-3 growth factors receptor 1
- Tyrosine-protein kinase Lck 1
- Dual specificity protein kinase CLK1 1
- CDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7 1
- Protein kinase C delta type 1
- NT-3 growth factor receptor 1
- G protein-coupled receptor kinase 5 1
- G protein-coupled receptor kinase 4 1
- Dual specificity protein kinase CLK3 1
- Dual specificity protein kinase CLK2 1
- High affinity nerve growth factor receptor 1
- G protein-coupled receptor kinase 6 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Potassium voltage-gated channel subfamily H member 2 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-2 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Calcium/calmodulin-dependent protein kinase type 1D 1
- Fibroblast growth factor receptor 4 1
- Tyrosine-protein kinase Fgr 1
- Aurora kinase B 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Cytochrome P450 3A4 1
- Aurora kinase C 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- Ribosomal protein S6 kinase alpha-4 1
- Maternal embryonic leucine zipper kinase 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- ...
Publications 1 ▿
- Bioorg Med Chem Lett 30: (2020) 314
Institutions 1 ▿
- [Merck & Co.] 314
Affinity: 9 to 1.0E+5 nM▿
- IC50 313
- EC50 1
- Affinity ≤ nM
Xtal structures: 2
Docked structures: 0
Catalog Cmpds: 1